Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Dec;98(6):627-33.
doi: 10.1007/s12185-013-1433-6. Epub 2013 Sep 18.

TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells

Yoshikane Kikushige  1 , Toshihiro Miyamoto
Affiliations
Review

TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells

Yoshikane Kikushige et al. Int J Hematol. 2013 Dec.

Abstract

Acute myelogenous leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), which represent the ultimate therapeutic target for AML. Recent studies have identified several AML LSC-specific surface antigens as candidate targets of therapeutic molecules. T cell immunoglobulin mucin-3 (TIM-3) is expressed on LSCs in most types of AML, with the exception of acute promyelocytic leukemia, but not on normal hematopoietic stem cells (HSCs). In xenograft models reconstituted with human AML LSCs or HSCs, an anti-human TIM-3 mouse IgG2a antibody with cytotoxic activities eradicates AML LSCs in vivo, but does not affect normal human hematopoiesis. Thus, TIM-3 is a promising therapeutic target for the eradication of AML LSCs.

PubMed Disclaimer

References

    1. Blood. 2012 Apr 19;119(16):3734-43 - PubMed
    1. Curr Opin Immunol. 2007 Apr;19(2):239-45 - PubMed
    1. Nat Immunol. 2004 Jul;5(7):738-43 - PubMed
    1. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11008-13 - PubMed
    1. Cell Stem Cell. 2009 Jul 2;5(1):31-42 - PubMed

MeSH terms