Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Feb;58(2):443-8.
doi: 10.1128/iai.58.2.443-448.1990.

Invasion and replication of Salmonella typhimurium in animal cells

L C Gahring  1 , F Heffron, B B Finlay, S Falkow
Affiliations

Invasion and replication of Salmonella typhimurium in animal cells

L C Gahring et al. Infect Immun. 1990 Feb.

Abstract

A total of 81 avirulent Tn10 insertion mutants of Salmonella typhimurium have previously been described. These mutants were selected for the inability to survive in murine macrophages. We have characterized the abilities of the most avirulent of these mutants to adhere to, invade, and replicate in both macrophages and nonphagocytic epithelial cells. The results suggest that most mutants contain a defect that is specific to survival within professional phagocytes. These mutants invaded and replicated normally within nonphagocytic human colon adenocarcinoma cells (Caco-2) but did not survive in the macrophage cell line J774. One mutant invaded both macrophages and epithelial cells much less efficiently than the parental strain. The defect associated with this mutant appears to be a result of decreased adherence to animal cells.

PubMed Disclaimer

References

    1. J Exp Med. 1966 Oct 1;124(4):573-83 - PubMed
    1. Biochimie. 1988 Aug;70(8):1089-99 - PubMed
    1. Infect Immun. 1977 Aug;17(2):290-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5173-7 - PubMed
    1. Infect Immun. 1978 Dec;22(3):804-9 - PubMed

Publication types

Substances

LinkOut - more resources