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. 2013 Jul;4(7):744-7.

Effect of 50% hydro-ethanolic leaf extracts of ruellia tuberosa L. And dipteracanthus patulus (jacq.) on lipid profile in alloxan induced diabetic rats

Manikandan Ananthakrishnan  1 , Victor Arokia Doss
Affiliations

Effect of 50% hydro-ethanolic leaf extracts of ruellia tuberosa L. And dipteracanthus patulus (jacq.) on lipid profile in alloxan induced diabetic rats

Manikandan Ananthakrishnan et al. Int J Prev Med. 2013 Jul.

Abstract

Background: The study was undertaken to investigate the effect of 50% hydro -ethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on lipid profile in alloxan induced diabetic rats.

Method: In lipid profile the parameters studied were serum total cholesterol, phospholipids, triglycerides, HDL-c, LDL-c and VLDL-c level. Extracts were orally administered daily for 30 days at a dosage of 250 and 500 mg/kg bodyweight to alloxan induced diabetic rats.

Results: The levels of phospholipids, triglycerides, LDL-c and VLDL-c were significantly (P < 0.05) reduced. The HDL-c level was found to be increased in the treatment groups. Total cholesterol level was found to be significantly (P < 0.05) decreased at 500 mg/kg bodyweight of both the plant extracts treated groups.

Conclusion: The results further suggests that the effect of plant extract treated groups was found to be lower in reducing the lipid levels in serum when compared to the drug (Glibenclamide 600 μg/kg body weight) treated group.

Keywords: Dipteracanthus patulus (Jacq.); Ruellia tuberosa L; lipid profile.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Effect of 50% hydroethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on cholesterol, triglycerides, and phospholipid levels in the serum of alloxan induced diabetic rats
Figure 2
Figure 2
Effect of 50% hydroethanolic leaf extracts of Ruellia tuberosa L. and Dipteracanthus patulus (Jacq.) on HDL, LDL, and VLDL-cholesterol levels in serum of alloxan induced diabetic rats
See this image and copyright information in PMC

References

    1. Mutalik S, Sulochana B, Chetana M, Udupa N, Uma Devi P. Preliminary studies on acute and subacute toxicity of an antidiabetic herbal preparation, Dianex. Indian J Exp Biol. 2003;41:316–20. - PubMed
    1. Morel DW, Chisolm GM. Antioxidant treatment of diabetes rats inhibits lipoprotein oxidation and cytotoxicity. J Lipid Res. 1989;30:1827–34. - PubMed
    1. Anturlikar SD, Gopumadhavan S, Chauhan BL, Mitra SK. Effect of D-400, a herbal formulation on blood sugar of normal and alloxan-induced diabetic rats. Indian J Physiol Pharmacol. 1995;39:95–100. - PubMed
    1. Chiu NY, Chang KH. The illustrated medicinal plants of Taiwan. Mingtong Med J. 1995;226:1.
    1. Murugesa MK. 6th ed. Madras: Directorate of Siddha System of Medicine; 1988. Materia Medica (Vegetable Section), Part 1, (Commentary), (in Tamil) p. 361.

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