Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec 17:2012:382862.
doi: 10.5402/2012/382862. eCollection 2012.

sTREM-1 as a Prognostic Marker of Postoperative Complications in Cardiac Surgery

A S Golovkin  1 , V G Matveeva, E V Grigoriev, D L Shukevich, Y V Bayrakova, L S Barbarash
Affiliations

sTREM-1 as a Prognostic Marker of Postoperative Complications in Cardiac Surgery

A S Golovkin et al. ISRN Inflamm. .

Abstract

Cell-activating receptor TREM-1 (triggering receptor expressed on myeloid cells 1) regulates congenital immune response and contributes to systemic inflammatory response syndrome (SIRS) development. It is able to multiply cytokine production while stimulated together with the main receptors of the congenital immune system. The purpose of the paper is to study the potential use of soluble TREM-1 (sTREM-1) as a marker of intensive SIRS and a criterion for postoperative complications prediction following on-pump coronary artery bypass surgery (CABG). Results show that early postoperative sTREM-1 concentrations demonstrate their potential prognostic value regarding SIRS-associated complications.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Dynamics of serum sTREM-1 increase rate in the different patient groups.
See this image and copyright information in PMC

References

    1. Bone RC, Sibbald WJ, Sprung CL. The ACCP-SCCM consensus conference on sepsis and organ failure. Chest. 1992;101(6):1481–1483. - PubMed
    1. Chereshnev VA, Gusev EI, Zotova NV. Fundamental-applied aspects of systemic inflammation in terms of physiologic and typical pathological process. Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova. 2010;96(7):696–707. - PubMed
    1. Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001;410(6832):1103–1107. - PubMed
    1. Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA. Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. Journal of Leukocyte Biology. 2006;80(6):1454–1461. - PubMed
    1. Ferat-Osorio E, Esquivel-Callejas N, Wong-Baeza I, et al. The increased expression of TREM-1 on monocytes is associated with infectious and noninfectious inflammatory processes. Journal of Surgical Research. 2008;150(1):110–117. - PubMed

LinkOut - more resources