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. 2013 Mar 17:2013:817901.
doi: 10.1155/2013/817901. eCollection 2013.

Perioperative Dynamics of TLR2, TLR4, and TREM-1 Expression in Monocyte Subpopulations in the Setting of On-Pump Coronary Artery Bypass Surgery

A S Golovkin  1 , V G Matveeva, I V Kudryavtsev, M N Chernova, Y V Bayrakova, D L Shukevich, E V Grigoriev
Affiliations

Perioperative Dynamics of TLR2, TLR4, and TREM-1 Expression in Monocyte Subpopulations in the Setting of On-Pump Coronary Artery Bypass Surgery

A S Golovkin et al. ISRN Inflamm. .

Abstract

Hypercytokinemia plays a key role in the pathogenesis of systemic inflammatory response syndrome (SIRS). Monocytes are the main source of cytokines in the early inflammatory phase. Simultaneous stimulation of toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells (TREM-1) activating receptor on monocytes results in the amplification of the inflammatory signal and multiple increase in proinflammatory cytokine production. The dynamics of those receptors expression on monocyte surface of patients with uncomplicated SIRS course followed coronary artery bypass surgery (CABG) was studied. The increase in TLR2 and TREM-1 expression on the first day after CABG induces proinflammatory and amplification potentials of monocytes in that period. The decrease in TLR2 surface expression on the seventh day compared to the preoperative values can be regarded as a mechanism limiting inflammatory response. The highest level of TLR2, TLR4, and TREM-1 surface expression was observed in CD14(hi)CD16(+) monocyte subpopulation, confirming its proinflammatory profile.

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Figures

Figure 1
Figure 1
Monocytes subpopulations.
Figure 2
Figure 2
The mean intensity of fluorescence of TLR2, TLR4, and TREM-1 surface expression.
See this image and copyright information in PMC

References

    1. Mei YQ, Ji Q, Liu H, et al. Study on the relationship of APACHE III and levels of cytokines in patients with systemic inflammatory response syndrome after coronary artery bypass grafting. Biological and Pharmaceutical Bulletin. 2007;30(3):410–414. - PubMed
    1. Snell A, Parizkova B. Organ damage during cardiopulmonary bypass. In: Ghosh S, Falter F, Cook DJ, editors. Cardiopulmonary Bypass. Cambridge University Press; 2009. pp. 140–153.
    1. Chereshnev VA, Gusev Yu E. Immunological and Pathophysiological mechanisms of Systemic Inflammation. Medical Immunology. 2012;14(1-2):9–20.
    1. Midwood KS, Piccinini AM. DAMPening inflammation by modulating TLR signalling. Mediators of Inflammation. 2010;2010:21 pages.672395 - PMC - PubMed
    1. Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nature Reviews Immunology. 2010;10(12):826–837. - PMC - PubMed

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