Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2013 Sep 18;5(9):3696-712.
doi: 10.3390/nu5093696.

Lycopene supplement and blood pressure: an updated meta-analysis of intervention trials

Xinli Li  1 , Jiuhong Xu
Affiliations
Meta-Analysis

Lycopene supplement and blood pressure: an updated meta-analysis of intervention trials

Xinli Li et al. Nutrients. .

Abstract

Epidemiological studies suggested that lycopene supplement could decrease blood pressure, but the results were conflicting. We conducted an updated meta-analysis by screening PubMed databases, and calculated the combined effect size using a random effect model. In addition, subgroup analysis stratified by baseline blood pressure, lycopene dosage, duration, study location and the funding support of the paper was also conducted. Six studies met our inclusion criteria, and the pooled analysis demonstrated a significant reduction of systolic blood pressure (SBP) (mean SBP = -4.953 [-8.820, -1.086], p = 0.012) with obvious heterogeneity (p = 0.034, I2 = 58.5%). Subgroup analysis results showed that higher dosage of lycopene supplement (>12 mg/day) could lower SBP more significantly, especially for participants with baseline SBP >120 mmHg, or Asians, while lycopene intervention had no statistical effect on diastolic blood pressure (DBP) (mean DBP = -3.809 [-8.177, 0.560], p = 0.087), and obvious heterogeneity was also observed (p = 0.074, I2 = 53.1%). Our present study suggests that lycopene supplement >12 mg/day might effectively decrease SBP, particularly among Asians or population with higher baseline SBP.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram of paper search.
Figure 2
Figure 2
Meta-analysis of the effect of lycopene on blood pressure in the random effect model. WMD, weighted mean difference. (A): Systolic blood pressure; (B): Diastolic blood pressure.
Figure 3
Figure 3
Funnel plot analysis to detect publication bias. (A): Systolic blood pressure; (B): Diastolic blood pressure.
See this image and copyright information in PMC

References

    1. 1999 World Health Organization-International society of hypertension guidelines for the management of hypertension. J. Hypertens. 1999;17:151–183. - PubMed
    1. The sixth report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch. Intern. Med. 1997;157:2413–2446. doi: 10.1001/archinte.1997.00440420033005. - DOI - PubMed
    1. Widlansky M.E., Gokce N., Keaney J.F., Jr., Vita J.A. The clinical implications of endothelial dysfunction. J. Am. Coll. Cardiol. 2003;42:1149–1160. doi: 10.1016/S0735-1097(03)00994-X. - DOI - PubMed
    1. Grassi D., Desideri G., Ferri L., Aggio A., Tiberti S., Ferri C. Oxidative stress endothelial dysfunction: Say NO to Cigarette Smoking! Curr. Pharm. Des. 2010;16:2539–2550. doi: 10.2174/138161210792062867. - DOI - PubMed
    1. Ernst E. Complementary/alternative medicine for hypertension: A mini-review. Wien. Med. Wochenschr. 2005;155:386–391. doi: 10.1007/s10354-005-0205-1. - DOI - PubMed

Publication types