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Review
. 2013 Jul;18(3):199-208.
doi: 10.5863/1551-6776-18.3.199.

Management strategies for neonatal hypoglycemia

Courtney B Sweet  1 , Stephanie Grayson, Mark Polak
Affiliations
Review

Management strategies for neonatal hypoglycemia

Courtney B Sweet et al. J Pediatr Pharmacol Ther. 2013 Jul.

Abstract

While hypoglycemia occurs commonly among neonates, treatment can be challenging if hypoglycemia persists beyond the first few days of life. This review discusses the available treatment options for both transient and persistent neonatal hypoglycemia. These treatment options include dextrose infusions, glucagon, glucocorticoids, diazoxide, octreotide, and nifedipine. A stepwise, practical approach to the management of these patients is offered.

Keywords: diazoxide; glucagon; hyperinsulinism; hypoglycemia; nifedipine; octreotide.

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Figures

Figure.
Figure.
Treatment Strategies. D10, dextrose 10%; FAO, fatty acid oxidation; FFA, free fatty acids; GN, genzymes (gluconeogenesis enzymes); GSD, glycogen storage disease.
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References

    1. Cornblath M, Odell GB, Levin GY. Symptomatic neonatal hypoglycemia associated with toxemia of pregnancy. J Pediatr. 1959;55:545–562. - PubMed
    1. Collins JE, Leonard JV. Hyperinsulinism in asphyxiated and small for dates infant with hypoglycemia. Lancet. 1984;2(8398):311–313. - PubMed
    1. Persson B, Hanson U, Marcus C. Gestational diabetes mellitus and paradoxical macrosomia: a case report. Early Hum Dev. 1995;41(3):203–213. - PubMed
    1. Zaffanello M, Zamboni G, Maffeis C. Neonatal hyperinsulinemic hypoglycemia: two case reports. Minerva Pediatr. 2002;54(4):325–333. et al. - PubMed
    1. De Leon DD, Stanley CA. Mechanisms of disease: advances in diagnosis and treatment of hyperinsulinism in neonates. Nat Clin Pract Endocrinol Metab. 2007;3(1):57–68. - PubMed