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. 2013 Apr 24:2013:453682.
doi: 10.1155/2013/453682. eCollection 2013.

A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity

Vyankat A Sontakke  1 , Sougata Ghosh, Pravin P Lawande, Balu A Chopade, Vaishali S Shinde
Affiliations

A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity

Vyankat A Sontakke et al. ISRN Org Chem. .

Abstract

A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell lines.

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Figures

Scheme 1
Scheme 1
Synthesis of 2-aryl benzimidazole.
Scheme 2
Scheme 2
Synthesis of bisbenzimidazole.
Scheme 3
Scheme 3
Plausible mechanism towards the formation of 2-aryl benzimidazole.
See this image and copyright information in PMC

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