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Editorial
. 2013 Sep;13(9):1009-12.
doi: 10.1586/14737140.2013.825424.

Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts

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Editorial

Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts

Alexey V Danilov et al. Expert Rev Anticancer Ther. 2013 Sep.
No abstract available

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References

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    1. Brenner H, Gondos A, Pulte D. Trends in long-term survival of patients with chronic lymphocytic leukemia from the 1980s to the early 21st century. Blood. 2008;111(10):4916–4921. - PubMed
    1. Danilov AV, Danilova OV, Klein AK, Huber BT. Molecular pathogenesis of chronic lymphocytic leukemia. Curr Mol Med. 2006;6(6):665–675. - PubMed
    1. Vogler M, Butterworth M, Majid A, et al. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Blood. 2009;113(18):4403–4413. Describes lymph node-mimicking coculture system. Implicates upregulation of BCLX and BFL1/BCL2A1 in resistance to ABT-737. - PubMed
    1. Tromp JM, Tonino SH, Elias JA, et al. Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering. Oncogene. 2010;29(36):5071–5082. Describes a dichotomy in NF.B signaling under CD40/TLR9 signaling in CLL. - PubMed

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