Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013;138(1):60-7.

Biomarkers for the management of pre-eclampsia in pregnant women

Lakshmi Tanuja Petla  1 , Rosy Chikkala, K S Ratnakar, Vijayalakshmi Kodati, V Sritharan
Affiliations
Review

Biomarkers for the management of pre-eclampsia in pregnant women

Lakshmi Tanuja Petla et al. Indian J Med Res. 2013.

Abstract

Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in placenta and is characterized by widespread maternal endothelial dysfunction. Till date, delivery of placenta is the only cure for the disease. So, there is a need for the identification of highly specific and sensitive biochemical markers that would allow early identification of patients at risk and thus help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination, that may help in predicting women who are likely to develop PE. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in predicting pre-eclampsia.

PubMed Disclaimer

Figures

Fig
Fig
Flow diagram showing process of pathogenesis of pre-eclampsia.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Haig D. Genetic conflicts in human pregnancy. Q Rev Biol. 1993;68:495–532. - PubMed
    1. Aernout Luttun, Peter Carmeliet. Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered? J Clin Invest. 2003;111:600–2. - PMC - PubMed
    1. Mutter WP, Karumanchi SA. Molecular mechanisms of preeclampsia. Microvasc Res. 2008;75:1–8. - PMC - PubMed
    1. Noronha Neto C, de Souza AS, Amorim MM. Pre-eclampsia treatment according to scientific evidence. Rev Bras Ginecol Obstet. 2010;32:459–68. - PubMed
    1. Arora R, Ganguli RP, Swain S, Oumachigui A, Rajaram P. Determinants of maternal mortality in eclampsia in India. Aust N Z J Obstet Gynaecol. 1994;34:537–9.