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Review
. 2013 Sep 10:4:264.
doi: 10.3389/fmicb.2013.00264.

Quantification of viral infection dynamics in animal experiments

Shingo Iwami  1 , Yoshiki Koizumi, Hiroki Ikeda, Yusuke Kakizoe
Affiliations
Review

Quantification of viral infection dynamics in animal experiments

Shingo Iwami et al. Front Microbiol. .

Abstract

Analyzing the time-course of several viral infections using mathematical models based on experimental data can provide important quantitative insights regarding infection dynamics. Over the past decade, the importance and significance of mathematical modeling has been gaining recognition among virologists. In the near future, many animal models of human-specific infections and experimental data from high-throughput techniques will become available. This will provide us with the opportunity to develop new quantitative approaches, combining experimental and mathematical analyses. In this paper, we review the various quantitative analyses of viral infections and discuss their possible applications.

Keywords: animal experiment; computer simulation; mathematical modeling; quantification; virus infection.

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Figures

FIGURE 1
FIGURE 1
Concepts for combining animal models with mathematical modeling. These quantitative approaches are referred to as “computational virology.” This has the potential to provide novel insights into viral pathogenesis, the development of antiviral drugs, and the establishment of effective therapies against viral infections.
See this image and copyright information in PMC

References

    1. Althaus C. L, De Boer R. J. (2010). Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy. Mol. Syst. Biol. 6 348 10.1038/msb.2010.4 - DOI - PMC - PubMed
    1. Anderson R. M. (1991). The Kermack–McKendrick epidemic threshold theorem. Bull. Math. Biol. 53 3–32 10.1016/S0092-8240(05)80039-4 - DOI - PubMed
    1. Arita M., Ami Y., Wakita T., Shimizu H. (2008). Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model. J. Virol. 82 1787–1797 10.1128/JVI.01798-07 - DOI - PMC - PubMed
    1. Arita M., Nagata N., Iwata N., Ami Y., Suzaki Y., Mizuta K., et al. (2007). An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys. J. Virol. 81 9386–9395 10.1128/JVI.02856-06 - DOI - PMC - PubMed
    1. Baccam P., Beauchemin C. A., Macken C. A., Hayden F. G., Perelson A. S. (2006). Kinetics of influenza A virus infection in humans. J. Virol. 80 7590–7599 10.1128/JVI.01623-05 - DOI - PMC - PubMed

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