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Review
. 2013 Apr 1;2(2):e23828.
doi: 10.4161/jkst.23828.

Targeting the tumor microenvironment: JAK-STAT3 signaling

Eirini Bournazou  1 , Jacqueline Bromberg
Affiliations
Review

Targeting the tumor microenvironment: JAK-STAT3 signaling

Eirini Bournazou et al. JAKSTAT. .

Abstract

Persistent JAK-STAT3 signaling is implicated in many aspects of tumorigenesis. Apart from its tumor-intrinsic effects, STAT3 also exerts tumor-extrinsic effects, supporting tumor survival and metastasis. These involve the regulation of paracrine cytokine signaling, alterations in metastatic sites rendering these permissive for the growth of cancer cells and subversion of host immune responses to create an immunosuppressive environment. Targeting this signaling pathway is considered a novel promising therapeutic approach, especially in the context of tumor immunity. In this article, we will review to what extent JAK-STAT3-targeted therapies affect the tumor microenvironment and whether the observed effects underlie responsiveness to therapy.

Keywords: IL-6; JAK-STAT3 signaling; targeted therapies; tumor microenvironment.

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Figures

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Figure 1. The role of activated STAT3 and its molecular targets in tumorigenesis.
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Figure 2. Immunohistochemical (A) and immunofluorescent (B) images showing localization of activated STAT3 (red) on the edge of human breast tumors in association with myeloid (CD33+, green) cells.
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Figure 3. The STAT3-dependent cytokine network as a regulator of cellular interactions with the tumor stroma.
See this image and copyright information in PMC

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