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. 2013 Oct 4;15(19):5036-9.
doi: 10.1021/ol402370f. Epub 2013 Sep 23.

S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate

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Free article

S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate

Vaibhav P Mehta et al. Org Lett. .
Free article

Abstract

A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 °C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol.

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