S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate
- PMID: 24059700
- DOI: 10.1021/ol402370f
S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate
Abstract
A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 °C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol.
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