Hepatitis C: a mouse at the end of the tunnel
- PMID: 24060850
- PMCID: PMC3847570
- DOI: 10.1038/cr.2013.132
Hepatitis C: a mouse at the end of the tunnel
Abstract
Since its discovery in 1989, researchers strive after a small animal model for Hepatitis C virus infection, so far with very limited success. A study recently published in Nature now for the first time reports the recapitulation of the complete life cycle of this virus in inbred mice with a functional adaptive immune system.
Comment on
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Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.Nature. 2009 Feb 12;457(7231):882-6. doi: 10.1038/nature07684. Epub 2009 Jan 28. Nature. 2009. PMID: 19182773 Free PMC article.
References
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- Lohmann V, Körner F, Koch J, et al. Science. 1999. pp. 110–113. - PubMed
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