Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Oct;13(10):701-13.
doi: 10.1038/nrc3582.

Krüppel-like factors in cancer

Marie-Pier Tetreault  1 , Yizeng Yang, Jonathan P Katz
Affiliations
Review

Krüppel-like factors in cancer

Marie-Pier Tetreault et al. Nat Rev Cancer. 2013 Oct.

Abstract

Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9 - PubMed
    1. Gastroenterology. 2008 May;134(5):1521-31 - PubMed
    1. Cell. 2012 Nov 21;151(5):994-1004 - PubMed
    1. Biochim Biophys Acta. 2012 Oct;1823(10):1666-75 - PubMed
    1. Br J Cancer. 2002 Oct 21;87(9):1042-6 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources