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. 2013 Dec;57(12):6370-1.
doi: 10.1128/AAC.01683-13. Epub 2013 Sep 23.

In vitro susceptibility of Mycobacterium tuberculosis to trimethoprim and sulfonamides in France

Sirwan Muhammed Ameen  1 , Michel Drancourt
Affiliations

In vitro susceptibility of Mycobacterium tuberculosis to trimethoprim and sulfonamides in France

Sirwan Muhammed Ameen et al. Antimicrob Agents Chemother. 2013 Dec.

Abstract

Five type strains and 55 Mycobacterium tuberculosis complex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90 of 10 mg/liter. Two M. canettii isolates uniquely yielded silent mutations C156 → T and G238 → C in the folP1 gene. Combined with scarce published data, these data indicate that sulfamides could be considered alternative antituberculous antibiotics.

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