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Review
. 1990 Jan;149(4):237-40.
doi: 10.1007/BF02106280.

Prenatal treatment of congenital adrenal hyperplasia: report of a new case

G A Loeuille  1 , M David, M G Forest
Affiliations
Review

Prenatal treatment of congenital adrenal hyperplasia: report of a new case

G A Loeuille et al. Eur J Pediatr. 1990 Jan.

Abstract

A mother at risk for 21-hydroxylase deficiency was treated with oral dexamethasone (0.5 mg 12 hourly) from early pregnancy, in an attempt to prevent in utero virilization in case of a female fetus. Fetal karyotype was 46,XX, and because of a possible intra HLA recombination, treatment was continued to term. The newborn had a modest virilization and hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia (CAH). This observation and review of the literature suggest that efficient prenatal treatment of CAH requires a higher and more frequent dosage of dexamethasone.

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References

    1. Pediatrics. 1980 Aug;66(2):312-4 - PubMed
    1. JAMA. 1985 Feb 15;253(7):1015-20 - PubMed
    1. J Clin Endocrinol Metab. 1972 Jan;34(1):44-50 - PubMed
    1. Lancet. 1969 Jun 7;1(7606):1151-2 - PubMed
    1. Am J Obstet Gynecol. 1972 Apr 15;112(8):1095-100 - PubMed