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. 2013 Nov;89(5):1019-22.
doi: 10.4269/ajtmh.13-0121. Epub 2013 Sep 23.

Norovirus genogroup II gastroenteritis in hospitalized children in South India

Vipin Kumar Menon  1 , Rajiv Sarkar, Prabhakar Devarajan Moses, Indira Agarwal, Anna Simon, Gagandeep Kang
Affiliations

Norovirus genogroup II gastroenteritis in hospitalized children in South India

Vipin Kumar Menon et al. Am J Trop Med Hyg. 2013 Nov.

Abstract

The distribution of norovirus (NoV) genogroup II in children < 5 years of age admitted to a south Indian hospital with diarrhea was investigated. Viral RNA extracted from 282 stool samples were screened for NoV GII and positive amplicons sequenced. Twenty-eight (9.9%) had NoV GII infection with a median age of 6 months, with more severe episodes of diarrhea among infected (median Vesikari score 13, interquartile range [IQR] 10-15) than children without infection (median score 10, IQR 8-13, P = 0.002). The study documents NoV GII infections as an important cause of gastroenteritis and the genetic diversity of circulating strains.

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Figures

Figure 1.
Figure 1.
Distribution of norovirus genotypes among 28 children hospitalized with noroviral gastroenteritis in Vellore.
Figure 2.
Figure 2.
Dendrogram constructed using neighbor-joining of nucleotide sequences corresponding to a fragment of 468 bp of the ORF 1-2 region of the NoV capsid encoding gene. Bootstrap P values for 10,000 pseudoreplicates are shown.
See this image and copyright information in PMC

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