Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Aug;123(8):3204-6.
doi: 10.1172/jci70800.

Rapamycin, anti-aging, and avoiding the fate of Tithonus

Arlan Richardson  1
Affiliations
Comment

Rapamycin, anti-aging, and avoiding the fate of Tithonus

Arlan Richardson. J Clin Invest. 2013 Aug.

Abstract

The discovery that rapamycin increased the lifespan of mice was recognized by Science as one of the top 10 scientific breakthroughs of 2009. In addition to increasing lifespan, Neff and colleagues show that while rapamycin improves several functions/pathologies that change with age, it has little effect on the majority of the physiological and structural parameters they evaluated. What do these data tell us about the ability of rapamycin to delay aging and improve quality of life, i.e., prevent the fate of Tithonus?

PubMed Disclaimer

Comment on

  • Rapamycin extends murine lifespan but has limited effects on aging.
    Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. Neff F, et al. J Clin Invest. 2013 Aug;123(8):3272-91. doi: 10.1172/JCI67674. Epub 2013 Jul 25. J Clin Invest. 2013. PMID: 23863708 Free PMC article.

Similar articles

  • Rapamycin extends life- and health span because it slows aging.
    Blagosklonny MV. Blagosklonny MV. Aging (Albany NY). 2013 Aug;5(8):592-8. doi: 10.18632/aging.100591. Aging (Albany NY). 2013. PMID: 23934728 Free PMC article.
  • Rapamycin in mice.
    Swindell WR. Swindell WR. Aging (Albany NY). 2017 Sep 1;9(9):1941-1942. doi: 10.18632/aging.101289. Aging (Albany NY). 2017. PMID: 28876223 Free PMC article. No abstract available.
  • Rapamycin extends murine lifespan but has limited effects on aging.
    Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. Neff F, et al. J Clin Invest. 2013 Aug;123(8):3272-91. doi: 10.1172/JCI67674. Epub 2013 Jul 25. J Clin Invest. 2013. PMID: 23863708 Free PMC article.
  • Is Rapamycin a Dietary Restriction Mimetic?
    Unnikrishnan A, Kurup K, Salmon AB, Richardson A. Unnikrishnan A, et al. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):4-13. doi: 10.1093/gerona/glz060. J Gerontol A Biol Sci Med Sci. 2020. PMID: 30854544 Free PMC article. Review.
  • Koschei the immortal and anti-aging drugs.
    Blagosklonny MV. Blagosklonny MV. Cell Death Dis. 2014 Dec 4;5(12):e1552. doi: 10.1038/cddis.2014.520. Cell Death Dis. 2014. PMID: 25476900 Free PMC article. Review.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460(7253):392–395. - PMC - PubMed
    1. Neff F, et al. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest. 2013;123(8):3272–3291. doi: 10.1172/JCI67674. - DOI - PMC - PubMed
    1. Halloran J, et al. Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience. 2012;223:102–113. doi: 10.1016/j.neuroscience.2012.06.054. - DOI - PMC - PubMed
    1. Majumder S, et al. Life-long rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and NMDA signaling. Aging Cell. 2012;11(2):326–335. doi: 10.1111/j.1474-9726.2011.00791.x. - DOI - PMC - PubMed
    1. Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mTOR, amyloid-beta, and tau: Effects on cognitive impairments. J Biol Chem. 2010;285(17):13107–13120. doi: 10.1074/jbc.M110.100420. - DOI - PMC - PubMed

Publication types