Aquaporins in cancer

Abstract

Background: The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement, transport of fluid and cell migration.

Scope of the review: This review article summarizes our knowledge concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process.

Major conclusions: Tumor cells types express AQPs and a positive correlation exists between histological tumor grade and the AQP expression. Moreover, AQPs are involved also in tumor edema formation and angiogenesis in several solid and hematological tumors.

General significance: AQPs inhibition in endothelial and tumor cells might limit tumor growth and spread, suggesting a potential therapeutic use in the treatment of tumors. This article is part of a Special Issue entitled Aquaporins.

Keywords: Angiogenesis; Aquaporins; Edema; Glioblastoma; Tumor growth.