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Review
. 2014 Mar;38(3):299-303.
doi: 10.1016/j.leukres.2013.08.009. Epub 2013 Sep 6.

Extramedullary chronic lymphocytic leukemia: systematic analysis of cases reported between 1975 and 2012

Megan Ratterman  1 , Kimberly Kruczek  1 , Suela Sulo  2 , Tait D Shanafelt  3 , Neil E Kay  3 , Chadi Nabhan  4
Affiliations
Review

Extramedullary chronic lymphocytic leukemia: systematic analysis of cases reported between 1975 and 2012

Megan Ratterman et al. Leuk Res. 2014 Mar.

Abstract

The prognostic significance of extra-medullary chronic lymphocytic leukemia (EM-CLL) is unknown. We conducted a Medline database systematic search analyzing English language articles published between 1975 and 2012 identifying 192 cases. Patients with EM-CLL were more commonly treated than not (p < .001). Skin and central nervous system (CNS) were the most commonly reported sites of organ involvement. Survival after diagnosis of EM-CLL appeared to depend on the site of EM involvement. Prospective evaluation and further studies of EM-CLL are warranted.

Keywords: CLL; Chronic lymphocytic leukemia; Extra-medullary; Prognosis.

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