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Review
. 2013 Nov;14(11):737-48.
doi: 10.1038/nrm3675. Epub 2013 Sep 25.

Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche

Guiomar Solanas  1 , Salvador Aznar Benitah
Affiliations
Review

Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche

Guiomar Solanas et al. Nat Rev Mol Cell Biol. 2013 Nov.

Abstract

In the past years, our view of the molecular and cellular mechanisms that ensure the self-renewal of the skin has dramatically changed. Several populations of stem cells have been identified that differ in their spatio-temporal contribution to their compartment in steady-state and damaged conditions, suggesting that epidermal stem cell heterogeneity is far greater than previously anticipated. There is also increasing evidence that these different stem cells require a tightly controlled spatial and temporal communication between other skin residents to carry out their function.

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