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. 2014 Jan;57(1):102-9.
doi: 10.1007/s00125-013-3065-z. Epub 2013 Sep 25.

Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families

Abigail Fraser  1 , Catarina Almqvist, Henrik Larsson, Niklas Långström, Debbie A Lawlor
Affiliations

Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families

Abigail Fraser et al. Diabetologia. 2014 Jan.

Abstract

Aims/hypothesis: The aim of this study was to investigate the association between maternal diabetes in pregnancy and offspring cognitive ability and also to assess whether the association was due to intrauterine mechanisms or shared familial characteristics.

Methods: We linked national registers and conducted a prospective cohort study of singleton Swedish-born men to explore associations between maternal pregnancy diabetes and educational achievement at age 16 years, the age of completing compulsory education in Sweden (n = 391,545 men from 337,174 families, graduating in 1988-1997 and n = 326,033 men from 282,079 families, graduating in 1998-2009), and intelligence quotient (IQ) at the mandatory conscription examination at 18 years of age (n = 664,871 from 543,203 families).

Results: Among non-siblings, maternal diabetes in pregnancy was associated with lower offspring cognitive ability even after adjustment for maternal age at birth, parity, education, early-pregnancy BMI, offspring birth year, gestational age and birthweight. For example, in non-siblings, the IQ of men whose mothers had diabetes in their pregnancy was on average 1.36 points lower (95% CI -2.12, -0.60) than men whose mothers did not have diabetes. In comparison, we found no such association within sibships (mean difference 1.70; 95% CI -1.80, 5.21).

Conclusions/interpretation: The association between maternal diabetes in pregnancy and offspring cognitive outcomes is likely explained by shared familial characteristics and not by an intrauterine mechanism.

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Figures

Fig. 1
Fig. 1
Schematic representation of potential pathways linking maternal diabetes in pregnancy and offspring cognition
Fig. 2
Fig. 2
Study flow chart
See this image and copyright information in PMC

References

    1. Ornoy A. Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes. Pediatr Endocrinol Rev. 2005;3:104–113. - PubMed
    1. Silverman BL, Rizzo TA, Cho NH, Metzger BE. Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care. 1998;21(suppl 2):B142–B149. - PubMed
    1. Temple RC, Hardiman M, Pellegrini M, Horrocks L, Martinez-Cengotitabengoa MT. Cognitive function in 6- to 12-year-old offspring of women with type 1 diabetes. Diabet Med. 2011;28:845–848. doi: 10.1111/j.1464-5491.2011.03285.x. - DOI - PubMed
    1. Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehaviour of school age children born to diabetic mothers. Arch Dis Child Fetal Neonatal Ed. 1998;79:F94–F99. doi: 10.1136/fn.79.2.F94. - DOI - PMC - PubMed
    1. Nielsen GL, Dethlefsen C, Sorensen HT, Pedersen JF, Molsted-Pedersen L. Cognitive function and army rejection rate in young adult male offspring of women with diabetes. Diabetes Care. 2007;30:2827–2831. doi: 10.2337/dc07-1225. - DOI - PubMed

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