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. 2013 Jul-Aug;68(7-8):269-74.

Cytotoxic rocaglamide derivatives from Aglaia duppereana

Mona El-Neketi  1 , Weaam Ebrahim, Ngoc Tu Duong, Sahar Gedara, Farid Badria, Hassan-Elrady A Saad, Werner E G Müller, Peter Proksch
Affiliations
  • PMID: 24066511

Cytotoxic rocaglamide derivatives from Aglaia duppereana

Mona El-Neketi et al. Z Naturforsch C J Biosci. 2013 Jul-Aug.

Abstract

Phytochemical investigation of Aglaia duppereana flowers led to the isolation of a new rocaglamide derivative and twelve known congeners. The structure of the new compound was unambiguously elucidated by spectroscopic techniques (1D- and 2D-NMR, HRESIMS). The isolated compounds exhibited a potent cytotoxic activity against mouse lymphoma (L5178Y) cells with EC50 values ranging from 5.1 to 54.8 nM.

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