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Review
. 2013 Jul-Sep;26(3):585-96.
doi: 10.1177/039463201302600302.

Systemic lupus erythematosus: immunopathogenesis and novel therapeutic targets

E Beccastrini  1 , M M D'Elios, G Emmi, E Silvestri, D Squatrito, D Prisco, L Emmi
Affiliations
Free article
Review

Systemic lupus erythematosus: immunopathogenesis and novel therapeutic targets

E Beccastrini et al. Int J Immunopathol Pharmacol. 2013 Jul-Sep.
Free article

Abstract

Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.

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