Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 Apr;69(4):383-4.
doi: 10.1136/thoraxjnl-2013-203388. Epub 2013 Sep 24.

Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy

Joerg Mattes  1 , Vanessa E Murphy, Heather Powell, Peter G Gibson
Affiliations
Free PMC article
Randomized Controlled Trial

Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy

Joerg Mattes et al. Thorax. 2014 Apr.
Free PMC article

Abstract

Objective: Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are strongly associated with the development of childhood asthma.

Methods: We conducted a follow-up study of infants born to women with asthma who completed a double-blind randomised controlled trial during pregnancy. In this trial, pregnant women with asthma were assigned to treatment adjustment by an algorithm using clinical symptoms (clinical group) or the fraction of exhaled nitric oxide (FeNO group) and we showed that the FeNO group had significantly lower asthma exacerbation rates in pregnancy.

Results: 146 infants attended the 12-month follow-up visit. Infants born to mothers from the FeNO group were significantly less likely to have recurrent episodes of bronchiolitis in the first year of life (OR 0.08, 95% CI 0.01 to 0.62; p=0.016) as compared with the clinical group.

Conclusions: Optimised management of asthma during pregnancy may reduce recurrent episodes of bronchiolitis in infancy, which could potentially modulate the risk to develop or the severity of emerging childhood asthma.

Keywords: Asthma.

PubMed Disclaimer

References

    1. Carroll KN, Gebretsadik T, Griffin MR, et al. Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy. Pediatrics 2007;119:1104–12 - PubMed
    1. Kuiper S, Muris JW, Dompeling E, et al. Interactive effect of family history and environmental factors on respiratory tract-related morbidity in infancy. J Allergy Clin Immunol 2007;120:388–95 - PubMed
    1. Powell H, Murphy VE, Taylor DR, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet 2011;378:983–90 - PubMed
    1. Powell CV, McNamara P, Solis A, et al. A parent completed questionnaire to describe the patterns of wheezing and other respiratory symptoms in infants and preschool children. Arch Dis Child 2002;87:376–9 - PMC - PubMed
    1. Murphy V, Namazy J, Powell H, et al. The risk of congenital malformations, perinatal mortality and neonatal hospitalisation among pregnant women with asthma: a systematic review and meta-analysis. BJOG 2013;120:812–22 - PubMed

Publication types

MeSH terms