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Review
. 2013 Sep 23:4:294.
doi: 10.3389/fimmu.2013.00294.

Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

Sari Lehtimäki  1 , Riitta Lahesmaa
Affiliations
Review

Regulatory T Cells Control Immune Responses through Their Non-Redundant Tissue Specific Features

Sari Lehtimäki et al. Front Immunol. .

Abstract

Regulatory T cells (Treg) are needed in the control of immune responses and to maintain immune homeostasis. Of this subtype of regulatory lymphocytes, the most potent are Foxp3 expressing CD4+ T cells, which can be roughly divided into two main groups; natural Treg cells (nTreg), developing in the thymus, and induced or adaptive Treg cells (iTreg), developing in the periphery from naïve, conventional T cells. Both nTreg cells and iTreg cells have their own, non-redundant roles in the immune system, with nTreg cells mainly maintaining tolerance toward self-structures, and iTreg developing in response to externally delivered antigens or commensal microbes. In addition, Treg cells acquire tissue specific features and are adapted to function in the tissue they reside. This review will focus on some specific features of Treg cells in different compartments of the body.

Keywords: immunity; microbiota; regulatory T cell; systems biology; tissue specificity; tolerance.

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References

    1. Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 30:636–4510.1016/j.immuni.2009.04.010 - DOI - PubMed
    1. Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet (2001) 27:20–110.1038/83713 - DOI - PubMed
    1. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 27:68–7310.1038/83784 - DOI - PubMed
    1. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 22:329–4110.1016/j.immuni.2005.01.016 - DOI - PubMed
    1. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 299:1057–6110.1126/science.1079490 - DOI - PubMed