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. 2013:2013:259080.
doi: 10.1155/2013/259080. Epub 2013 Aug 29.

A case of pulmonary tumor thrombotic microangiopathy diagnosed by transbronchial lung biopsy and treated with chemotherapy and long-term oxygen and anticoagulation therapies

Atsushi Kitamura  1 , Naoki Nishimura, Torahiko Jinta, Rika Suda, Yasuhiko Yamano, Genta Ishikawa, Yutaka Tomishima, Tsuyoshi Hamaoka, Koyu Suzuki, Naohiko Chohnabayashi
Affiliations

A case of pulmonary tumor thrombotic microangiopathy diagnosed by transbronchial lung biopsy and treated with chemotherapy and long-term oxygen and anticoagulation therapies

Atsushi Kitamura et al. Case Rep Pulmonol. 2013.

Abstract

A 41-year-old woman, who underwent breast resection for cancer of the right breast and adjuvant chemotherapy 2 years ago, was admitted to our hospital due to shortness of breath upon exertion. High-resolution computed tomography of the chest showed small nodular opacities in the peribronchiolar area in both lungs, as well as mediastinal and hilar lymphadenopathy. A transbronchial lung biopsy revealed breast cancer metastasis and pulmonary tumor thrombotic microangiopathy (PTTM). Treatment of PTTM is rarely reported due to the difficulty of antemortem diagnosis; however, the patient was effectively treated with chemotherapy and oxygen and anticoagulation therapies for 3 months.

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Figures

Figure 1
Figure 1
Computer tomography scans of the chest revealed ground glass opacities around the bronchovascular bundles in the lower lobe of the right lung.
Figure 2
Figure 2
A lung perfusion scan showed multiple wedge-shaped perfusion defects in both lungs.
Figure 3
Figure 3
Obstruction of the pulmonary artery and endothelial fibrocystic hyperplasia was determined by transbronchial lung biopsy specimens from the lower lobe of the right lung (hematoxylin and eosin staining, ×40).
See this image and copyright information in PMC

References

    1. von Herbay A, Illes A, Waldherr R, Otto HF. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer. 1990;66(3):587–592. - PubMed
    1. Guimarães MD, Almeida MFA, Brelinger A, Barbosa PN, Chojniak R, Gross JL. Diffuse bronchiolitis pattern on a computed tomography scan as a presentation of pulmonary tumor thrombotic microangiopathy: a case report. Journal of Medical Case Reports. 2011;5(article 575) - PMC - PubMed
    1. Sakashita N, Yokose C, Fujii K, Matsumoto M, Ohnishi K, Takeya M. Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach. Pathology International. 2007;57(6):383–387. - PubMed
    1. Kuwabara H, Yoshida S, Takasu T, et al. Pulmonary tumor thrombotic microangiopathy caused by gastric cancer. Annals of Thoracic Medicine. 2012;7(3):168–169. - PMC - PubMed
    1. Kim HJ, Kwak MH, Kong SY, et al. A case of locally advanced breast cancer complicated by pulmonary tumor thrombotic microangiopathy. Cancer Research and Treatment. 2012;44(4):267–270. - PMC - PubMed

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