[Tubular renal acidosis]

Abstract

Renal tubular acidosis (RTAs) are a group of metabolic disorders characterized by metabolic acidosis with normal plasma anion gap. There are three main forms of RTA: a proximal RTA called type II and a distal RTA (type I and IV). The RTA type II is a consequence of the inability of the proximal tubule to reabsorb bicarbonate. The distal RTA is associated with the inability to excrete the daily acid load and may be associated with hyperkalaemia (type IV) or hypokalemia (type I). The most common etiology of RTA type IV is the hypoaldosteronism. The RTAs can be complicated by nephrocalcinosis and obstructive nephrolithiasis. Alkalinization is the cornerstone of treatment.

Keywords: Acidose tubulaire distale; Acidose tubulaire proximale; Distal tubular renal acidosis; Nephrocalcinosis; Néphrocalcinose; Proximal tubular renal acidosis; Trou anionique urinaire; Urinary anionic gap.