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Comment
. 2013 Oct;45(10):1107-8.
doi: 10.1038/ng.2769.

Complex genetics of drug resistance in Mycobacterium tuberculosis

Digby F Warner  1 , Valerie Mizrahi
Affiliations
Comment

Complex genetics of drug resistance in Mycobacterium tuberculosis

Digby F Warner et al. Nat Genet. 2013 Oct.

Abstract

Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.

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References

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