Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Nov 14;49(88):10376-8.
doi: 10.1039/c3cc45551c.

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

Lei Hu  1 , Fredrik Schaufelberger, Yan Zhang, Olof Ramström
Affiliations

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

Lei Hu et al. Chem Commun (Camb). .

Abstract

The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.

PubMed Disclaimer

Publication types