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. 2014 Feb;22(2):55-61.
doi: 10.1007/s12471-013-0472-1.

Adoption of prasugrel into routine practice: rationale and design of the Rijnmond Collective Cardiology Research (CCR) study in percutaneous coronary intervention for acute coronary syndromes

T Yetgin  1 , M M J M van der Linden, A G de Vries, P C Smits, E Boersma, R-J M van Geuns, F Zijlstra; CCR Study Investigators
Affiliations

Adoption of prasugrel into routine practice: rationale and design of the Rijnmond Collective Cardiology Research (CCR) study in percutaneous coronary intervention for acute coronary syndromes

T Yetgin et al. Neth Heart J. 2014 Feb.

Abstract

Background: Platelet inhibition is crucial in reducing both short- and long-term atherothrombotic risks in patients with acute coronary syndromes (ACS) managed with percutaneous coronary intervention (PCI). Based on randomised trials, recent recommendations in the current guidelines include the endorsement of prasugrel as a first-choice adenosine diphosphate receptor inhibitor. Yet, there is limited experience with the use of prasugrel in routine practice.

Methods: The Rijnmond Collective Cardiology Research (CCR) registry is a prospective, observational study that will follow-up 4000 PCI-treated ACS patients in the larger region of Rotterdam, the Netherlands. Based on recently implemented hospital protocols, all patients will receive prasugrel as first-choice antiplatelet agent, unless contraindicated, in accordance with European guidelines, and will be followed for up to 1 year post-discharge for longitudinal assessment of outcomes and bleeding events. This registry exemplifies a collaborative study design that employs a regional PCI registry platform and provides feedback to participating sites regarding their practice patterns, thereby supporting and promoting improvement of quality of care.

Conclusion: The CCR registry will evaluate the adoption of prasugrel into routine clinical practice and thus, will provide important evidence with regard to the benefits and risks of real-world utilisation of prasugrel as antiplatelet therapy in PCI-treated ACS patients.

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Figures

Fig. 1
Fig. 1
Longitudinal study design of the CCR study. *Clopidogrel 600 mg loading dose and 75 mg/daily maintenance dose when prasugrel is contraindicated. ACS indicates acute coronary syndrome; CABG coronary artery bypass grafting; CV cardiovascular; LD loading dose; MACE major adverse cardiac events; MD maintenance dose; MI myocardial infarction; PCI percutaneous coronary intervention; ST stent thrombosis; and TVR target vessel revascularisation
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References

    1. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358(9281):527–33. doi: 10.1016/S0140-6736(01)05701-4. - DOI - PubMed
    1. Patrono C, Bachmann F, Baigent C, et al. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology. Eur Heart J. 2004;25(2):166–81. doi: 10.1016/j.ehj.2003.10.013. - DOI - PubMed
    1. Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494–502. doi: 10.1056/NEJMoa010746. - DOI - PubMed
    1. Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360(4):354–62. doi: 10.1056/NEJMoa0809171. - DOI - PubMed
    1. Serebruany VL, Steinhubl SR, Berger PB, et al. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol. 2005;45(2):246–51. doi: 10.1016/j.jacc.2004.09.067. - DOI - PubMed

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