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. 2013 Sep;7(5):524-31.
doi: 10.5009/gnl.2013.7.5.524. Epub 2013 Jun 11.

Prevalence of proximal serrated polyps and conventional adenomas in an asymptomatic average-risk screening population

Chang Kyun Lee  1 , Youn Wha Kim, Jae-Jun Shim, Jae Young Jang
Affiliations

Prevalence of proximal serrated polyps and conventional adenomas in an asymptomatic average-risk screening population

Chang Kyun Lee et al. Gut Liver. 2013 Sep.

Abstract

Background/aims: Detection of proximal serrated polyps (PSPs) is increasingly recognized as a new qualitative target for colonoscopy. The aims of this study were to assess the detected prevalence of PSPs and synchronous adenomas in an asymptomatic average-risk screening cohort and to evaluate potential factors associated with detection of PSPs.

Methods: The study included 1,375 asymptomatic average-risk Korean patients (aged 50 years or older) who underwent screening colonoscopy. In total, 1,710 polyps were evaluated pathologically.

Results: The overall PSP detection rate (PSPDR) was low at 3.1%, despite high polyp (54.0%) and adenoma detection rates (ADRs, 43.5%). ADR did not correlate with PSPDR, but it was strongly correlated with PDR (r=0.810; p<0.001). Patients with PSPs were more likely to have longer withdrawal time and more proximal colon adenomas than patients without PSPs (adjusted odds ratio [OR], 1.19; 95% confidence interval [CI], 1.09 to 1.31; p<0.001) (adjusted OR, 2.03; 95% CI, 1.06 to 3.88; p=0.031, respectively).

Conclusions: The detected prevalence of PSPs was low (<5%) in an asymptomatic average-risk screening Korean population, despite the high prevalence of conventional adenomas. A longer mucosal inspection of the proximal colon may serve as a practical method to enhance detection of PSPs.

Keywords: Colonic polyps; Colonoscopy; Colorectal neoplasms; Prevalence.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Overall flow of study enrollment and case identification.
Fig. 2
Fig. 2
Examples of high-risk (cytological dysplasia or ≥10 mm diameter) proximal serrated polyps detected in the study population. (A) Hyperplastic polyp located in the appendiceal orifice, 12 mm, Paris classification 0-IIb (*). (B) Sessile serrated adenoma/polyp (SSA/P) with dysplasia in the hepatic flexure, 30 mm, Paris classification 0-IIa. (C) SSA/P without dysplasia in the transverse colon, 17 mm, Paris classification 0-IIa. (D) SSA/P without dysplasia in the transverse colon, 20 mm, Paris classification IIb (*).
See this image and copyright information in PMC

References

    1. Rex DK, Petrini JL, Baron TH, et al. Quality indicators for colonoscopy. Am J Gastroenterol. 2006;101:873–885. - PubMed
    1. Kaminski MF, Regula J, Kraszewska E, et al. Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med. 2010;362:1795–1803. - PubMed
    1. Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2009;150:1–8. - PubMed
    1. Brenner H, Hoffmeister M, Arndt V, Stegmaier C, Altenhofen L, Haug U. Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study. J Natl Cancer Inst. 2010;102:89–95. - PubMed
    1. Lasisi F, Rex DK. Improving protection against proximal colon cancer by colonoscopy. Expert Rev Gastroenterol Hepatol. 2011;5:745–754. - PubMed

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