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Review
. 2013:2013:346067.
doi: 10.1155/2013/346067. Epub 2013 Aug 29.

Developmental origins of chronic renal disease: an integrative hypothesis

F Boubred  1 , M Saint-Faust, C Buffat, I Ligi, I Grandvuillemin, U Simeoni
Affiliations
Review

Developmental origins of chronic renal disease: an integrative hypothesis

F Boubred et al. Int J Nephrol. 2013.

Abstract

Cardiovascular diseases are one of the leading causes of mortality. Hypertension (HT) is one of the principal risk factors associated with death. Chronic kidney disease (CKD), which is probably underestimated, increases the risk and the severity of adverse cardiovascular events. It is now recognized that low birth weight is a risk factor for these diseases, and this relationship is amplified by a rapid catch-up growth or overfeeding during infancy or childhood. The pathophysiological and molecular mechanisms involved in the "early programming" of CKD are multiple and partially understood. It has been proposed that the developmental programming of arterial hypertension and chronic kidney disease is related to a reduced nephron endowment. However, this mechanism is still discussed. This review discusses the complex relationship between birth weight and nephron endowment and how early growth and nutrition influence long term HT and CKD. We hypothesize that fetal environment reduces moderately the nephron number which appears insufficient by itself to induce long term diseases. Reduced nephron number constitutes a "factor of vulnerability" when additional factors, in particular a rapid postnatal growth or overfeeding, promote the early onset of diseases through a complex combination of various pathophysiological pathways.

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Figures

Figure 1
Figure 1
Factors influencing nephron endowment.
Figure 2
Figure 2
Proposed pathophysiological mechanism of renal injury (glomerular endothelium barrier disruption, podocyte dysfunction, interstitial fibrosis, tubular ischemia). FSA: filtration surface area; GFR: glomerular filtration rate; SNGFR: single nephron glomerular filtration rate; RAS: rennin angiotensin system; VEGF: vascular endothelial growth factor system; ∑: sympathetic nervous system.
Figure 3
Figure 3
Developmental origin of hypertension and chronic kidney disease: an “integrative hypothesis”.
See this image and copyright information in PMC

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