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Comment
. 2013 Sep 26;155(1):15-6.
doi: 10.1016/j.cell.2013.09.012.

For genomes to stay in shape, insulators must be up to PAR

Patrick J Wijchers  1 , Wouter de Laat
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For genomes to stay in shape, insulators must be up to PAR

Patrick J Wijchers et al. Cell. .
Free article

Abstract

Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

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