Mitofusins: mighty regulators of metabolism
- PMID: 24074856
- DOI: 10.1016/j.cell.2013.09.013
Mitofusins: mighty regulators of metabolism
Abstract
Mitochondria are central regulators of cellular metabolism but how their function in a subset of cells affects whole-body energy balance is less understood. Two studies in this issue of Cell identify how diet-dependent modulation of mitochondrial fusion in specific neuronal circuits impact the metabolic status of an animal.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.Cell. 2013 Sep 26;155(1):172-87. doi: 10.1016/j.cell.2013.09.003. Cell. 2013. PMID: 24074867 Free PMC article.
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Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.Cell. 2013 Sep 26;155(1):188-99. doi: 10.1016/j.cell.2013.09.004. Cell. 2013. PMID: 24074868 Free PMC article.
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