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Comment
. 2013 Sep 26;155(1):19-20.
doi: 10.1016/j.cell.2013.09.010.

Cerebral organoids in a dish: progress and prospects

Marina Bershteyn  1 , Arnold R Kriegstein
Affiliations
Comment

Cerebral organoids in a dish: progress and prospects

Marina Bershteyn et al. Cell. .

Abstract

A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.

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Figures

Figure 1
Figure 1. Generation of 3D Endodermal and Ectodermal Organoids from Skin Fibroblasts
Reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) enables in vitro differentiation into tissue-specific progenitors, such as intestinal stem cells, thyroid, or neuroectodermal progenitors. When grown under the right conditions in suspension, these progenitors self-organize into 3D tissues resembling the intestine, thyroid, optic cup, or cerebral cortex.
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