TERRA -a calling card for telomerase
- PMID: 24074950
- DOI: 10.1016/j.molcel.2013.09.011
TERRA -a calling card for telomerase
Abstract
Transcription of telomeric DNA has long been thought to inhibit telomerase. Using live cell imaging, in this issue, Cusanelli et al. (2013) now reveal a different scenario: telomeric RNA is preferentially generated at short telomeres and delivers telomerase to the chromosome end from which the transcript originated.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres.Mol Cell. 2013 Sep 26;51(6):780-91. doi: 10.1016/j.molcel.2013.08.029. Mol Cell. 2013. PMID: 24074956
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