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Comment
. 2013 Sep 26;51(6):705-6.
doi: 10.1016/j.molcel.2013.09.012.

Circuitous route to transcription regulation

Mohan T Bolisetty  1 , Brenton R Graveley
Affiliations
Comment

Circuitous route to transcription regulation

Mohan T Bolisetty et al. Mol Cell. .

Abstract

In this issue of Molecular Cell, Zhang and colleagues (2013) identify a new class of intron-derived circular RNAs (ciRNAs) and show that they have the potential to enhance transcription of their host gene.

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Figures

Figure 1
Figure 1. Stable circular intron RNAs (ciRNAs) enhance host gene transcription
ciRNAs are generated from lariat introns that escape debranching. Sequences near the 5’ splice site (red box) and branch point (purple box) are minimally sufficient for an intron to escape debranching and become a stable ciRNA. The stable ciRNA binds to elongating RNA Polymerase II and enhances transcription.
See this image and copyright information in PMC

Comment on

  • Circular intronic long noncoding RNAs.
    Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L, Chen LL. Zhang Y, et al. Mol Cell. 2013 Sep 26;51(6):792-806. doi: 10.1016/j.molcel.2013.08.017. Epub 2013 Sep 12. Mol Cell. 2013. PMID: 24035497

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