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Comment
. 2013 Dec;37(6):553-5.
doi: 10.1016/j.clinre.2013.08.005. Epub 2013 Sep 25.

Fat accretion in a subpopulation of hepatocytes as a strategy to protect the whole liver against oxidative stress and lipotoxicity

B Fromenty  1
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Fat accretion in a subpopulation of hepatocytes as a strategy to protect the whole liver against oxidative stress and lipotoxicity

B Fromenty. Clin Res Hepatol Gastroenterol. 2013 Dec.

Abstract

Fatty liver can be induced by obesity, some drugs and alcohol intoxication. In this liver lesion, lipid accumulation can involve only some hepatocytes but the significance of this cell-to-cell heterogeneity is unknown. In a recent work, Dr Pol et al. propose that high-fat hepatocytes could protect the cell population against oxidative stress and lipotoxicity.

Keywords: DAG; Diacylglycerol; FFA; Free fatty acid; LD; Lipid droplet; ROS; Reactive oxygen species; TAG; Triacylglycerol; WAT; White adipose tissue.

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