Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer
- PMID: 24075202
- DOI: 10.1016/j.celrep.2013.09.008
Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer
Abstract
In this issue of Cell Reports, Li et al. show that the analysis of genetic changes in patient-derived xenografts can reveal crucial details of tumor evolution, such as the emergence of functional estrogen receptor mutations in endocrine-resistant breast cancer.
Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Comment on
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Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.Cell Rep. 2013 Sep 26;4(6):1116-30. doi: 10.1016/j.celrep.2013.08.022. Epub 2013 Sep 19. Cell Rep. 2013. PMID: 24055055 Free PMC article.
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