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. 2013 Nov-Dec;34(6):676-81.
doi: 10.1016/j.amjoto.2013.05.002. Epub 2013 Sep 26.

Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes

Masoud Movahedi  1 , Ali Akbar Amirzargar, Rasoul Nasiri, Armin Hirbod-Mobarakeh, Elham Farhadi, Marzieh Tavakol, Nasrin Behniafard, Bita Ansaripour, Batoul Moradi, Ahad Zare, Nima Rezaei
Affiliations
Free article

Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes

Masoud Movahedi et al. Am J Otolaryngol. 2013 Nov-Dec.
Free article

Abstract

Background: Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. T-helper (Th)2 cytokines seems to have major roles behind the scene of unpleasant symptoms resulted from AR. Expression of interleukin (IL)-4 and its receptor could be affected by single nucleotide polymorphisms (SNPs). This study assessed the effect of 4 genetic variants within genes of IL-4 and IL-4R in AR.

Methods: Allele frequencies of one IL-4R variant (rs1801275) and three SNPs of IL-4 (rs2243248, rs2243250, and rs2070874) were investigated in 98 patients with AR, compared to a group of controls, using PCR sequence-specific-primers (PCR-SSP) method.

Results: Homozygosity for the C allele of rs2243250 in IL-4 was significantly overrepresented in the patient group. CC genotype in rs2070874 significantly was correlated with AR. GG/CC/CC and TT/TT/TT (rs2243248, rs2243250, and rs2070874) haplotypes in the IL-4 gene had a significant negative correlation with AR.

Conclusion: SNPs in IL-4 are associated with AR and could change the clinical picture of the disease in patients.

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