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Review
. 2013 Dec;18(23-24):1323-33.
doi: 10.1016/j.drudis.2013.09.010. Epub 2013 Sep 25.

Advances in the development of Rho-associated protein kinase (ROCK) inhibitors

Peichen Pan  1 , Mingyun Shen, Huidong Yu, Youyong Li, Dan Li, Tingjun Hou
Affiliations
Review

Advances in the development of Rho-associated protein kinase (ROCK) inhibitors

Peichen Pan et al. Drug Discov Today. 2013 Dec.

Abstract

Rho-associated protein kinases (ROCK1 and ROCK2) belong to the AGC family of serine-threonine kinases, and regulate a wide range of fundamental cell functions. Inhibition of ROCK has been proven to be of potential therapeutic benefit for a variety of diseases. In this review, the structures and therapeutic importance of ROCK are discussed briefly. Then, the recent status of the development of ROCK inhibitors is also summarized. Our review offers a foundation outline from which strategies to design new leads against ROCK can be developed.

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