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Editorial
. 2013 Oct 29;128(18):2002-4.
doi: 10.1161/CIRCULATIONAHA.113.006092. Epub 2013 Sep 27.

UnTEThering (smooth muscle) cell plasticity

Domenick A Prosdocimo  1 , Rajan Jain, Mukesh K Jain
Affiliations
Editorial

UnTEThering (smooth muscle) cell plasticity

Domenick A Prosdocimo et al. Circulation. .
No abstract available

Keywords: DNA methylation; Editorials; TET2 protein, human; epigenomics; muscle, smooth.

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Figures

Figure
Figure
Ten-eleven translocation-2 (TET2) is an epigenetic regulator of vascular smooth muscle cell (VSMC) phenotype plasticity through a mechanism involving the oxidation of 5-methylcytosine (5-mC) and generation of 5-hydroxymethylcytosine (5-hmC). Myocd indicates Myocardin; and SRF, serum response factor.
See this image and copyright information in PMC

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References

    1. Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation. 2013;128:2047–2057. - PMC - PubMed
    1. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767–801. - PubMed
    1. Chamley-Campbell J, Campbell GR, Ross R. The smooth muscle cell in culture. Physiol Rev. 1979;59:1–61. - PubMed
    1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801–809. - PubMed
    1. Gomez D, Owens GK. Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovasc Res. 2012;95:156–164. - PMC - PubMed

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