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Observational Study
. 2014 Jan;55(1):95-8.
doi: 10.2967/jnumed.113.127266. Epub 2013 Sep 27.

Clinical Cerenkov luminescence imaging of (18)F-FDG

Daniel L J Thorek  1 , Christopher C Riedl, Jan Grimm
Affiliations
Observational Study

Clinical Cerenkov luminescence imaging of (18)F-FDG

Daniel L J Thorek et al. J Nucl Med. 2014 Jan.

Abstract

The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease.

Methods: Patients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal (18)F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera.

Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using (18)F-FDG. Imaging of patients revealed the presence of (18)F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established.

Conclusion: CL imaging with diagnostic doses of (18)F-FDG is feasible and can aid in detecting disease in the clinical setting.

Keywords: 18F-FDG; Cerenkov luminescence imaging; PET/CT; clinical.

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Conflict of interest statement

DISCLOSURE

No other potential conflict of interest relevant to this article was reported.

Figures

FIGURE 1
FIGURE 1
Sensitivity and linearity of intensified CCD to detect CL from 18F-FDG. (A) CL imaging of multiwell plate with activity at 1 and 0.1 MBq/mL. (B) Linearity analysis of background-subtracted and decay-corrected region of interest of CL photon flux from wells using intensified CCD with settings optimized for the activity concentrations.
FIGURE 2
FIGURE 2
Representative CL and PET/CT images of 18F-FDG–positive axillary lymph node. (A and B) CL scans of right and left axillae, respectively. (C) Negative CL scan in light-protected environment of right axilla without 18F-FDG–positive lymph node, overlaid with white-light photograph. No significant CL emission from 18F-FDG decay is seen. (D) White-light photograph from left axilla, overlaid with significant CL signal (B). (E) This signal colocalized with PET/CT finding.
FIGURE 3
FIGURE 3
(A) Correlation graph between PET (MBq/mL max) and CL imaging count rate. (B) Box plot comparing Cerenkov emission from pathologic, PET-positive lymph nodes vs. contralateral PET-negative control, demonstrating significantly higher signal from PET-positive side.
See this image and copyright information in PMC

Comment in

  • Reply: Human Cerenkov imaging using 18F-FDG.
    Thorek DL, Riedl CC, Grimm J. Thorek DL, et al. J Nucl Med. 2014 Mar;55(3):523-4. doi: 10.2967/jnumed.113.135533. Epub 2014 Jan 21. J Nucl Med. 2014. PMID: 24449595 No abstract available.
  • Human Cerenkov imaging using 18F-FDG.
    Spinelli AE, Boschi F. Spinelli AE, et al. J Nucl Med. 2014 Mar;55(3):523. doi: 10.2967/jnumed.113.135384. Epub 2014 Jan 21. J Nucl Med. 2014. PMID: 24449596 No abstract available.

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