Adipose-derived stem cells for cartilage regeneration--moving towards clinical applicability
- PMID: 24079605
- PMCID: PMC3854774
- DOI: 10.1186/scrt329
Adipose-derived stem cells for cartilage regeneration--moving towards clinical applicability
Abstract
Despite multiple methods of treatment and a wealth of research in the field of regenerative medicine focusing on cartilage defects, the management of cartilage injuries remains a challenge. A recent study by Van Pham and colleagues proposes a method for preconditioning autologous adipose-derived stem cells. Their study offers evidence about the increased proliferative and chondrogenetic capabilities of platelet-rich plasma-treated adipose-derived stem cells and the increased efficiency of these in treating articular cartilage defects in mice. Even though the method needs further elaboration and the composition of the repair tissue requires investigation, the results are promising for the design of clinically acceptable cell therapies aimed at cartilage regeneration.
Comment on
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Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage.Stem Cell Res Ther. 2013 Aug 1;4(4):91. doi: 10.1186/scrt277. Stem Cell Res Ther. 2013. PMID: 23915433 Free PMC article.
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