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Comment
. 2013 Oct;84(4):639-41.
doi: 10.1038/ki.2013.198.

Dietary phosphate: the challenges of exploring its role in FGF23 regulation

Marta Christov  1 , Harald Jüppner
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Free article
Comment

Dietary phosphate: the challenges of exploring its role in FGF23 regulation

Marta Christov et al. Kidney Int. 2013 Oct.
Free article

Abstract

Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate homeostasis, yet efforts to control its circulating levels by manipulating dietary phosphate intake in humans and animals with normal or impaired kidney function have yielded conflicting results. In the study by Zhang et al., severe phosphate restriction in a genetic mouse model of progressive kidney dysfunction failed to cause a uniform FGF23 reduction, again highlighting the complexity of FGF23 regulation.

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