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Review
. 2013;98(4):254-66.
doi: 10.1159/000355632. Epub 2013 Sep 21.

Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders

Elizabeth K Nousen  1 , Juliana G Franco, Elinor L Sullivan
Affiliations
Review

Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders

Elizabeth K Nousen et al. Neuroendocrinology. 2013.

Abstract

The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed. © 2013 S. Karger AG, Basel.

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Figures

Fig. 1
Fig. 1
The bidirectional relationship and overlapping mechanisms of MetS and MHDs.
See this image and copyright information in PMC

References

    1. Alberti KG, et al. The metabolic syndrome--a new worldwide definition. Lancet. 2005;366(9491):1059–62. - PubMed
    1. Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5–6):231–7. - PMC - PubMed
    1. Weiss R. Childhood metabolic syndrome: must we define it to deal with it? Diabetes Care. 2011;34(Suppl 2):S171–6. - PMC - PubMed
    1. Cook S, et al. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988–1994. Arch Pediatr Adolesc Med. 2003;157(8):821–7. - PubMed
    1. Prevention, C.f.D.C.a; U.S.D.o.H.a.H. Services, editor Obesity Trends Among US Adults Between 1985 and 2010.

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