Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)

Affiliations

Affiliation

¹ Department of Respiratory Medicine and German Center of Lung Research (DZL), Hannover Medical School, Hannover, Germany (K.M.O., M.M.H.); Department of Pneumology, University Hospitals of Leuven, Leuven, Belgium (M.D.); University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Hannover, Germany (H.A.G., H.T.); Department of Rheumatology and Clinical Immunology, Charité University Hospital, and Epidemiology unit, German Rheumatism Research Centre, Berlin, Germany (D.H.); Clinic of Internal Medicine, University Hospital, Zurich, Switzerland (R.S.); University Hospital Heidelberg, Heidelberg, Germany (E.G.); Medical Clinic I, Clinic Loewenstein, Loewenstein, Germany (G.S.); Clinic III for Internal Medicine (Cardiology), and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany (S.R.); Internal Medicine I, University Hospital Carl Gustav Carus of Technical University Dresden, Dresden, Germany (M. Halank); Department of Internal Medicine, Respiratory Medicine and Cardiology, Mission Medical Hospital, Würzburg, Germany (M. Held); Department of Internal Medicine II, Division of Pneumology, University Medical Center Regensburg, Regensburg, Germany (T.J.L.); Department of Internal Medicine V, University of Munich, Munich, Germany (J.B.); University Medical Center Hamburg-Eppendorf, Center of Oncology, Department of Respiratory Medicine, Hamburg, Germany (H. Klose); LungenClinic Grosshansdorf, Germany (M.C.); Clinic of Internal Medicine, Department of Respiratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.E.); Department of Cardiology, DRK Kliniken Berlin Köpenick, Berlin, Germany (C.F.O.); Department of Cardiovascular and Respiratory Diseases, Sapienza, University of Rome; Rome, Italy (C.D.V.); Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy (L.S.); Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands (A.V.-N.); Dep

PMID: 24081973
DOI: 10.1161/CIRCULATIONAHA.113.004526

Observational Study

Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)

Karen M Olsson et al. Circulation. 2014.

. 2014 Jan 7;129(1):57-65.

doi: 10.1161/CIRCULATIONAHA.113.004526. Epub 2013 Sep 30.

Affiliation

¹ Department of Respiratory Medicine and German Center of Lung Research (DZL), Hannover Medical School, Hannover, Germany (K.M.O., M.M.H.); Department of Pneumology, University Hospitals of Leuven, Leuven, Belgium (M.D.); University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Hannover, Germany (H.A.G., H.T.); Department of Rheumatology and Clinical Immunology, Charité University Hospital, and Epidemiology unit, German Rheumatism Research Centre, Berlin, Germany (D.H.); Clinic of Internal Medicine, University Hospital, Zurich, Switzerland (R.S.); University Hospital Heidelberg, Heidelberg, Germany (E.G.); Medical Clinic I, Clinic Loewenstein, Loewenstein, Germany (G.S.); Clinic III for Internal Medicine (Cardiology), and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany (S.R.); Internal Medicine I, University Hospital Carl Gustav Carus of Technical University Dresden, Dresden, Germany (M. Halank); Department of Internal Medicine, Respiratory Medicine and Cardiology, Mission Medical Hospital, Würzburg, Germany (M. Held); Department of Internal Medicine II, Division of Pneumology, University Medical Center Regensburg, Regensburg, Germany (T.J.L.); Department of Internal Medicine V, University of Munich, Munich, Germany (J.B.); University Medical Center Hamburg-Eppendorf, Center of Oncology, Department of Respiratory Medicine, Hamburg, Germany (H. Klose); LungenClinic Grosshansdorf, Germany (M.C.); Clinic of Internal Medicine, Department of Respiratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.E.); Department of Cardiology, DRK Kliniken Berlin Köpenick, Berlin, Germany (C.F.O.); Department of Cardiovascular and Respiratory Diseases, Sapienza, University of Rome; Rome, Italy (C.D.V.); Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy (L.S.); Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands (A.V.-N.); Dep

PMID: 24081973
DOI: 10.1161/CIRCULATIONAHA.113.004526

Abstract

Background: For almost 30 years, anticoagulation has been recommended for patients with idiopathic pulmonary arterial hypertension (IPAH). Supporting evidence, however, is limited, and it is unclear whether this recommendation is still justified in the modern management era and whether it should be extended to patients with other forms of pulmonary arterial hypertension (PAH).

Methods and results: We analyzed data from Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA), an ongoing European pulmonary hypertension registry. Survival rates of patients with IPAH and other forms of PAH were compared by the use of anticoagulation. The sample consisted of 1283 consecutively enrolled patients with newly diagnosed PAH. Anticoagulation was used in 66% of 800 patients with IPAH and in 43% of 483 patients with other forms of PAH. In patients with IPAH, there was a significantly better 3-year survival (P=0.006) in patients on anticoagulation compared with patients who never received anticoagulation, albeit the patients in the anticoagulation group had more severe disease at baseline. The survival difference at 3 years remained statistically significant (P=0.017) in a matched-pair analysis of n=336 IPAH patients. The beneficial effect of anticoagulation on survival of IPAH patients was confirmed by Cox multivariable regression analysis (hazard ratio, 0.79; 95% confidence interval, 0.66-0.94). In contrast, the use of anticoagulants was not associated with a survival benefit in patients with other forms of PAH.

Conclusions: The present data suggest that the use of anticoagulation is associated with a survival benefit in patients with IPAH, supporting current treatment recommendations. The evidence remains inconclusive for other forms of PAH.

Clinical trial registration url: http://www.clinicaltrials.gov. Unique identifier: NCT01347216.

Keywords: anticoagulation; pulmonary hypertension; survival; therapy.

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Comment in

Letter by Suissa and Galié regarding article, "Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)".
Suissa S, Galié N. Suissa S, et al. Circulation. 2014 Sep 16;130(12):e107. doi: 10.1161/CIRCULATIONAHA.113.007666. Circulation. 2014. PMID: 25223777 No abstract available.
Letter by Bertoletti et al regarding article, "Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)".
Bertoletti L, Mismetti P, Decousus H. Bertoletti L, et al. Circulation. 2014 Sep 16;130(12):e108. doi: 10.1161/CIRCULATIONAHA.113.007143. Circulation. 2014. PMID: 25223778 No abstract available.
Letter by Ogawa and Matsubara regarding article, "Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)".
Ogawa A, Matsubara H. Ogawa A, et al. Circulation. 2014 Sep 16;130(12):e109. doi: 10.1161/CIRCULATIONAHA.114.009780. Circulation. 2014. PMID: 25223779 No abstract available.
Response to letters regarding article, "Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)".
Olsson KM, Delcroix M, Ghofrani HA, Tiede H, Huscher D, Speich R, Grünig E, Staehler G, Rosenkranz S, Halank M, Held M, Lange TJ, Behr J, Klose H, Claussen M, Ewert R, Opitz CF, Vizza CD, Scelsi L, Vonk-Noordegraaf A, Kaemmerer H, Gibbs JS, Coghlan G, Pepke-Zaba J, Schulz U, Gorenflo M, Pittrow D, Hoeper MM. Olsson KM, et al. Circulation. 2014 Sep 16;130(12):e110-2. doi: 10.1161/CIRCULATIONAHA.114.010921. Circulation. 2014. PMID: 25223780 No abstract available.

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Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)

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Anticoagulation and survival in pulmonary arterial hypertension: results from the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA)

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