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. 2013 Sep;58(5):406.
doi: 10.4103/0019-5154.117324.

Acrokeratosis verruciformis of hopf along lines of blaschko

Affiliations

Acrokeratosis verruciformis of hopf along lines of blaschko

Pragya A Nair. Indian J Dermatol. 2013 Sep.

Abstract

Acrokeratosis verruciformis of Hopf (AKV) is a rare genodermatosis presenting as multiple plane wart-like lesions symmetrically distributed on dorsum of hands and feet. Its pathogenesis is unknown. A case of 24 years old female is described with multiple hyperpigmented, hyperkeratotic papules on the left side of body since 5 years along the lines of Blaschko. Histopathology showed changes of AKV. Other unusual findings were the absence of family history, extensive lesions with flexural, and genital involvement.

Keywords: Acrokeratosis verruciformis of Hopf; genodermatosis; lines of blasckho.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Multiple hyperkeratotic, hyperpigmented papules in multiple bands over back of the left thigh
Figure 2
Figure 2
Discrete papules over (a) left upperback and shoulder, showing an inverted “U”-shaped pattern and (b) upper arm in the linear pattern, along the lines of Blaschko
Figure 3
Figure 3
AKV over the left side of the body along the lines of Blaschko
Figure 4
Figure 4
Histopathology shows hyperkeratosis, acanthosis, papillomatosis with circumscribed elevation of epidermis resembling church spires

References

    1. Panja RK. Acrokeratosis verruciformis: (Hopf): A clinical entity? Br J Dermatol. 1977;96:643–52. - PubMed
    1. Rege VL, Hede RV, Nadkarni NS. Acrokeratosis verruciformis of Hopf. Indian J Dermatol Venereol Leprol. 1992;58:95–8.
    1. Sarma N. Blaschko's Lines and Mosicism. In: Inamadar AC, Palit A, editors. Advances in Pediatric Dermatology. 1st ed. Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2011. pp. 69–82.
    1. Jackson R. The lines of Blaschko: A review and reconsideration: Observations of the cause of certain unusual linear conditions of the skin. Br J Dermatol. 1976;95:349–60. - PubMed
    1. Irvine AD, Mellerio JE. In Rook's Textbook of Dermatology. 8th ed. Oxford: Wiley – Blackwell; 2010. Genetics and genodermatosis; p. 15. 6.

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